A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics

Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications is of great interest. Here we screened >320.000 compounds for their ability to prevent a cellular lipid accumulation phenoty...

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ग्रंथसूची विवरण

मुख्य लेखकों:	Kirsten Tschapalda, Ya-Qin Zhang, Li Liu, Kseniya Golovnina, Thomas Schlemper, Thomas O. Eichmann, Madhu Lal-Nag, Urmila Sreenivasan, John McLenithan, Slava Ziegler, Carole Sztalryd, Achim Lass, Douglas Auld, Brian Oliver, Herbert Waldmann, Zhuyin Li, Min Shen, Matthew B. Boxer, Mathias Beller
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2016-06-01
श्रृंखला:	EBioMedicine
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2352396416301499
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