LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response

Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we set out to investigate the amount of DNA methyltransferase 1...

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Hlavní autoři:	Björn Koos, Eva Lotta Moderegger, Katharina Rump, Hartmuth Nowak, Katrin Willemsen, Caroline Holtkamp, Patrick Thon, Michael Adamzik, Tim Rahmel
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-10-01
Edice:	Cells
Témata:	sepsis mitochondrial DNA methylation
On-line přístup:	https://www.mdpi.com/2073-4409/9/10/2282
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