Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis

Sepsis is a life-threatening disease caused by the dysregulated host immune response to infection, which eventually leads to multi-organ failure. Current therapeutic strategies rely heavily on antibiotics. However, conventional antimicrobial therapy often leads to antibiotic abuse and resistance. Th...

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Detalhes bibliográficos

Principais autores:	Huanhuan Pang, Honglin Chen, Peng Chen, Xu Wei, Hongda Liu, Xueling He, Yang Yang, Junzhe Zhang, Dianfei Li, Linlin Lou, Wen Xie, Chong Qiu, Fei Xia, Qiuyan Guo, Shengnan Shen, Qiaoli Shi, Weiguang Li, Guang Han, Xijun Wang, Jigang Wang, Chengchao Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
coleção:	Acta Pharmaceutica Sinica B
Assuntos:	Inflammation Activity-based protein profiling (ABPP) Target identification Chemical proteomics Gambogenic acid (GNA) Hexokinase 1 (HK1)
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383525006975
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