HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation

The Herpes Simplex Virus (HSV-1) immediate-early protein ICP22 interacts with cellular proteins to inhibit host cell gene expression and promote viral gene expression. ICP22 inhibits phosphorylation of Ser2 of the RNA polymerase II (pol II) carboxyl-terminal domain (CTD) and productive elongation of...

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Principais autores:	Nur Firdaus Isa, Olivier Bensaude, Nadiah C. Aziz, Shona Murphy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-09-01
Colecção:	Vaccines
Assuntos:	cyclin-dependent kinase transcription elongation checkpoint tegument protein VP16 immediate-early protein amber codon suppression technology
Acesso em linha:	https://www.mdpi.com/2076-393X/9/10/1054
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