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Partial mitochondrial involvement in the antiproliferative and immunostimulatory effects of PT-112

PT-112 is a novel small molecule exhibiting promising clinical activity in patients with solid tumors. PT-112 kills malignant cells by inhibiting ribosome biogenesis while promoting the emission of immunostimulatory signals. Accordingly, PT-112 is an authentic immunogenic cell death (ICD) inducer an...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ruth Soler-Agesta, Manuel Beltrán-Visiedo, Ai Sato, Takahiro Yamazaki, Emma Guilbaud, Christina Y. Yim, Maria T. Congenie, Tyler D. Ames, Alberto Anel, Lorenzo Galluzzi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2025-12-01
Schriftenreihe:OncoImmunology
Schlagworte:
CGAS
CD8+ cytotoxic T lymphocytes
damage-associated molecular patterns
immune checkpoint inhibitors
mtDNA
PD-1
Online-Zugang:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2507245
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