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ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens like enzalutamide (ENZ) in castration‐resistant prostate cancer (CRPC) is a major clinical challenge, yet the role in the tumor microenvironment remains poorly understood. This study identifies a unique AR‐positive tumor‐associated macrophages (...

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Principais autores: Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-07-01
Serier:Advanced Science
Fag:
AR+ TAMs
CRPC
enzalutamide resistance
IL‐6 signaling
phagocytosis
Online adgang:https://doi.org/10.1002/advs.75290
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