No Genus-Specific Gene Is Essential for the Replication of Fowl Adenovirus 4 in Chicken LMH Cells

ABSTRACT Essential genus-specific genes have not been discovered for fowl adenovirus (FAdV), which hampers the development of FAdV-based vectors and attenuated FAdV vaccines. Reverse genetics approaches were employed to construct FAdV-4 mutants carrying deletions or frameshift mutations covering the...

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Principais autores:	Xinglong Liu, Xiaohui Zou, Wenfeng Zhang, Xiaojuan Guo, Min Wang, Yingtao Lv, Tao Hung, Zhuozhuang Lu
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2022-06-01
Serija:	Microbiology Spectrum
Teme:	fowl adenovirus essential gene reverse genetics virus rescue RNA-seq promoter
Online dostop:	https://journals.asm.org/doi/10.1128/spectrum.00470-22
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