Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory

A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the activity of the murine sequence and found tha...

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Principais autores:	Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz FM Passalacqua, Timothy Bredy, Marcelo A Wood, Andrej Luptak
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	eLife Sciences Publications Ltd 2024-02-01
סדרה:	eLife
נושאים:	CPEB3 ribozyme neuroplasticity
גישה מקוונת:	https://elifesciences.org/articles/90116
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