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Polyether antibiotics K-41A and K-41Am inhibit HIV-1 replication via suppressing the activities of HIV-1 reverse transcriptase and integrase

Introduction K-41A is a known compound with antibacterial activity against gram-positive bacteria and coccidia. In our screening of anti-HIV compounds, we found polyether antibiotic K-41A and its analogue K-41Am isolated from a marine-derived Streptomyces sp. SCSIO 01680 exhibited anti-HIV activity....

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Principais autores: Xin Liu, Jiemei Chu, Chun Gui, Weibo Liao, Fengxiang Qin, Xi Hu, Bingyu Liang, Junjun Jiang, Jiegang Huang, Chuanyi Ning, Jiang Chen, Jianhua Ju, Jingzhen Lai, Jie Liu, Bo Zhou, Li Ye, Hao Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Termedia Publishing House 2020-08-01
coleção:Archives of Medical Science
Assuntos:
anti-hiv-1
reverse transcriptase
integrase
molecular docking
Acesso em linha:https://www.archivesofmedicalscience.com/Polyether-antibiotics-K-41A-and-K-41Am-inhibit-nHIV-1-replication-via-suppressing,123933,0,2.html
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