S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson’s disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental factors causing a specific posttranslational...

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Principais autores:	Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B. McClatchy, Jolene K. Diedrich, John R. Yates, III, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A. Lipton
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2017-11-01
叢編:	Cell Reports
主題:	PARK6 PINK1 PARK2 Parkin Parkinson’s disease mitophagy S-nitrosylation
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2211124717315310
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