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HIF1α activation is associated with increased CaV3.2 expression and hypoxia-induced neuronal hyperexcitability

Transient insults to the brain can convert neurons chronically hyperexcitable. Key molecular mechanisms that link hypoxic events, e.g. in the context of episodic ischemia, to neuronal hyperexcitability remain vague. The transcription factor hypoxia-inducible factor 1α (HIF1α) is a central mediator o...

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Principais autores: Anna R. Tröscher, Despina Tsortouktzidis, Franziska Ammer-Pickhardt, Manuel Penzenleitner, Martin Aichholzer, Philip-Rudolf Rauch, Tobias Rossmann, Nico Stroh-Holly, Baran Atli, Andreas Gruber, Raimund Helbok, Jan Haubold, Christian Thome, Maren Engelhardt, Tim J. von Oertzen, Susanne Schoch, Albert J. Becker, Karen M.J. van Loo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-09-01
coleção:Neurobiology of Disease
Assuntos:
Ischemia
Epileptogenesis
Post-stroke epilepsy
Stroke
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996126002275
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