The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration

Abstract CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutations within the CBP gene are known to cause Rubinstein-Taybi syndrome (RSTS), a devel...

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Autors principals:	Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Severin Filser, Finn Peters, Jana Immenschuh, Malte Hellwig, Judith Niesen, Volker Mall, Birgit Ertl-Wagner, Christian Hagel, Michael Spohn, Beat Lutz, Jan Sedlacik, Daniela Indenbirken, Daniel J. Merk, Ulrich Schüller
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-12-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	Creb binding protein (CREBBP CBP) Rubinstein-Taybi syndrome (RSTS) Neural precursor cell migration Adult neurogenesis Neural differentiation
Accés en línia:	https://doi.org/10.1186/s40478-019-0849-5
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