Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases

We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time...

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Autors principals:	Milo Gatti, Giulio Virgili, Pier Giorgio Cojutti, Paolo Gaibani, Matteo Conti, Carmelo Sturiale, Federico Pea, Pierluigi Viale
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-01-01
Col·lecció:	Microorganisms
Matèries:	ceftazidime/avibactam CSF penetration post-neurosurgical ventriculitis KPC-producing <i>Klebsiella pneumoniae</i> carbapenem-resistant <i>Pseudomonas aeruginosa</i> fosfomycin
Accés en línia:	https://www.mdpi.com/2076-2607/10/1/154
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