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Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems

Therapeutic monoclonal antibodies (mAb) are used for the treatment of numerous serious diseases, which have led to an increasing demand over the last decades. Increased cell density and mAb titer of the cultivation broth lead to great challenges for the subsequent clarification and capture operation...

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Principais autores: Thomas Kruse, Axel Schmidt, Markus Kampmann, Jochen Strube
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2019-07-01
סדרה:Antibodies
נושאים:
aqueous two-phase extraction
phase separation
downstream
clarification
membrane
גישה מקוונת:https://www.mdpi.com/2073-4468/8/3/40
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