RNF213 governs divergent tumor-immune dynamics across human cancers: a prognostic biomarker for immunotherapy stratification

Abstract Purpose RNF213 encodes one of the largest E3 ubiquitin ligases in the human proteome, playing essential roles in ubiquitination, DNA damage repair, and immune system regulation. Although RNF213 has been extensively studied in Moyamoya disease, its involvement in cancer biology remains insuf...

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Hlavní autoři:	Jinpeng Wen, Zhekuan Lv, Mojiao Lu, Chuanming Zheng, Changtian Yin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer 2025-07-01
Edice:	Discover Oncology
Témata:	RNF213 Pan-cancer analysis Tumor microenvironment Immunotherapy Immune checkpoint blockade Prognostic biomarker
On-line přístup:	https://doi.org/10.1007/s12672-025-03237-0
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