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Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases

Abstract The aim is to investigate the evidence for shared genetic architecture between each of asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD). Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 4...

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Hlavní autoři: Tong Gong, Ralf Kuja-Halkola, Arvid Harder, Cecilia Lundholm, Awad I. Smew, Kelli Lehto, Anna Andreasson, Yi Lu, Nicholas J. Talley, Joëlle A. Pasman, Catarina Almqvist, Bronwyn K. Brew
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2024-09-01
Edice:Communications Biology
On-line přístup:https://doi.org/10.1038/s42003-024-06795-1
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