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β-cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by systemic insulin resistance and progressive deterioration of pancreatic β-cell function. Advances in single-cell transcriptomics, epigenomics, and spatial transcriptomics have delineated marked β-cell heterogeneity, revealing sub...

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Huvudupphov: Evgeny Ruchko, Maria Chernysheva, Vasily Sokolov, Zakhar Starinnov, Marat Sabirov, Andrey Vasiliev
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2026-01-01
Serie:Frontiers in Cell and Developmental Biology
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Länkar:https://www.frontiersin.org/articles/10.3389/fcell.2025.1698296/full
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