Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

Several previous studies have linked the Parkinson's disease (PD) gene LRRK2 to the biology of microglia cells. However, the precise ways in which LRRK2 affects microglial function have not been fully resolved. Here, we used the RNA-Sequencing to obtain transcriptomic profiles of LRRK2 wild-type (WT...

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主要な著者:	Isabella Russo, Alice Kaganovich, Jinhui Ding, Natalie Landeck, Adamantios Mamais, Tatiana Varanita, Alice Biosa, Isabella Tessari, Luigi Bubacco, Elisa Greggio, Mark R. Cookson
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2019-09-01
シリーズ:	Neurobiology of Disease
主題:	LRRK2 Microglia α-Synuclein Parkinson's disease Neuroinflammation Oxidative stress
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S096999611930124X
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