Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through PCSK9 variant: evidence from Mendelian randomization and animal experiments

BackgroundPolyunsaturated fatty acids (PUFAs), particularly ω-3 PUFAs, can improve sepsis prognosis. However, the relationship between the pre-infection levels of PUFAs and sepsis risk remains unclear.MethodsWe conducted a two-sample Mendelian randomization (MR) analysis using UK Biobank data to exp...

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Κύριοι συγγραφείς:	Qi Han, Zhengxuan Li, Qilong Song, Simeng He
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2026-01-01
Σειρά:	Frontiers in Medicine
Θέματα:	Mendelian randomization PCSK9 polyunsaturated fatty acids sepsis ω-3
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1701207/full
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