Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.

BACKGROUND: Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcircula...

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Autors principals:	Elena Nobili, M Dolores Salvado, Lasse Folkersen, Laura Castiglioni, Jens Kastrup, Anders Wetterholm, Elena Tremoli, Göran K Hansson, Luigi Sironi, Jesper Z Haeggström, Anders Gabrielsen
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2012-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC3404957?pdf=render
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