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Single-cell and bulk transcriptome analyses revealed the role of macrophage cholesterol metabolism in atherosclerosis

Abstract Background Atherosclerosis (AS) is a complex cardiovascular disease characterized by dysregulated macrophage cholesterol metabolism (CM), a central driver of foam cell formation and plaque progression. However, how macrophage CM becomes dysregulated is still not fully understood. Single-cel...

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Hlavní autoři: Jiaxing Ke, Shuling Chen, Lingjia Li, Chenxin Liao, Feng Peng, Dajun Chai, Jinxiu Lin
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2025-11-01
Edice:Lipids in Health and Disease
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On-line přístup:https://doi.org/10.1186/s12944-025-02773-6
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