ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability

The human zinc metalloprotease ZMPSTE24 is an integral membrane protein crucial for the final step in the biogenesis of the nuclear scaffold protein lamin A, encoded by LMNA. After farnesylation and carboxyl methylation of its C-terminal CAAX motif, the lamin A precursor (prelamin A) undergoes prote...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Eric D. Spear, Erh-Ting Hsu, Laiyin Nie, Elisabeth P. Carpenter, Christine A. Hrycyna, Susan Michaelis
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	The Company of Biologists 2018-07-01
श्रृंखला:	Disease Models & Mechanisms
विषय:	Lamin A processing Saccharomyces cerevisiae Ubiquitin-proteasome system Progeria disease
ऑनलाइन पहुंच:	http://dmm.biologists.org/content/11/7/dmm033670
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