Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure

Recently, we reported that homozygous deletion of alternative exon 33 of CaV1.2 calcium channel in the mouse resulted in ventricular arrhythmias arising from increased CaV1.2Δ33 ICaL current density in the cardiomyocytes. We wondered whether heterozygous deletion of exon 33 might produce cardiac phe...

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Bibliografische Detailangaben

Hauptverfasser:	Juejin Wang, Guang Li, Dejie Yu, Yuk Peng Wong, Tan Fong Yong, Mui Cheng Liang, Ping Liao, Roger Foo, Uta C. Hoppe, Tuck Wah Soong
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2018-01-01
Schriftenreihe:	Channels
Schlagworte:	alternative splicing cardiomyopathy CaV1.2 calcium channel heterozygous knockout Rbfox
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/19336950.2017.1381805
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