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The reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells

Abstract Sinus node (SN) pacemaking is based on a coupling between surface membrane ion-channels and intracellular Ca2+-handling. The fundamental role of the inward Na+/Ca2+ exchanger (NCX) is firmly established. However, little is known about the reverse mode exchange. A simulation study attributed...

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Bibliografiset tiedot
Päätekijät: Noémi Tóth, Axel Loewe, Jozefina Szlovák, Zsófia Kohajda, Gergő Bitay, Jouko Levijoki, Julius Gy. Papp, András Varró, Norbert Nagy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Portfolio 2022-12-01
Sarja:Scientific Reports
Linkit:https://doi.org/10.1038/s41598-022-25574-8
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