Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies

Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They are derivatives of immunoglobulins G (IgGs) that bind tumor antigens, such as Her2, IGF1-R, CD22, and LeY, with stabilized Dig-binding variabl...

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Detalhes bibliográficos

Principais autores:	Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein, Kerstin Jahn-Hofmann, Frieder Bauss, Weijun Cheng, Rebecca Croasdale, Karin Daub, Simone Dill, Eike Hoffmann, Wilma Lau, Helmut Burtscher, James L Ludtke, Silke Metz, Olaf Mundigl, Zane C Neal, Werner Scheuer, Jan Stracke, Hans Herweijer, Ulrjch Brinkmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2012-01-01
coleção:	Molecular Therapy: Nucleic Acids
Assuntos:	bispecific antibody dynamic polyconjugate hapten lipid nanoparticle RNA interference siRNA delivery
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2162253116301032
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