Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance

IntroductionResearch findings of the past decade have highlighted the gut as the main site of action of the oral antihyperglycemic agent metformin despite its pharmacological role in the liver. Extensive evidence supports metformin’s modulatory effect on the composition and function of gut microbiot...

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Bibliografische gegevens

Hoofdauteurs:	Monta Brīvība, Laila Silamiķele, Ineta Kalniņa, Ivars Silamiķelis, Līga Birzniece, Laura Ansone, Lauma Jagare, Ilze Elbere, Jānis Kloviņš
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2023-09-01
Reeks:	Frontiers in Endocrinology
Onderwerpen:	metformin NF-kappa B signaling humoral immune responses high-fat diet intestinal transcriptome
Online toegang:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1232143/full
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