Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4<sup>+ </sup>T lymphocytes in human lymphoid tissue <it>ex vivo</it>
<p>Abstract</p> <p>Background</p> <p>HIV-1 Nef critically contributes to AIDS in part by augmenting virus titers in infected individuals. Analyzing which of Nef's activities contribute to HIV pathogenesis has been hampered by the lack of a cell culture model in which Nef exerts pronounced effects on...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2009-01-01
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| Serie: | Retrovirology |
| Accesso online: | http://www.retrovirology.com/content/6/1/6 |
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