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Laboratory and genetic characteristic associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study

Abstract Sickle cell disease (SCD) is a hereditary disorder characterized by HBB variants, leading to chronic hemolytic anemia and vaso-occlusion. Hepatobiliary complications, including cholelithiasis, are common but underreported. This study investigated the rates and risk factors for cholelithiasi...

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Principais autores: André Rolim Belisário, Mina Cintho Ozahata, Isabel Cristina Gomes Moura, Carolina Miranda, Anna Bárbara Carneiro-Proietti, Ester Cerdeira Sabino, Alessandra Ferraz, Cláudia Máximo, Miriam V. Flor-Park, Daniela de Oliveira Werneck Rodrigues, Rosimere Afonso Mota, Brian Custer, Shannon Kelly, Carla Luana Dinardo, for the REDS-III Brazil SCD Cohort study and the TOPMed consortium
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2026-02-01
Serier:Annals of Hematology
Fag:
Sickle cell disease
Cholelithiasis
Hemolysis
Genome-wide association study
UGT1A1 variants
Online adgang:https://doi.org/10.1007/s00277-026-06800-z
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