Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Abstract Background Fragile X Syndrome (FXS) occurs as a result of a silenced fragile X mental retardation 1 gene (FMR1) and subsequent loss of fragile X mental retardation protein (FMRP) expression. Loss of FMRP alters excitatory/inhibitory signaling balance, leading to increased neuronal hyperexci...

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Detalhes bibliográficos

Principais autores:	Tori L. Schaefer, Matthew H. Davenport, Lindsay M. Grainger, Chandler K. Robinson, Anthony T. Earnheart, Melinda S. Stegman, Anna L. Lang, Amy A. Ashworth, Gemma Molinaro, Kimberly M. Huber, Craig A. Erickson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-06-01
coleção:	Journal of Neurodevelopmental Disorders
Assuntos:	Electrophysiology Hyperactivity Fragile X syndrome Anxiety Extracellular signal-related kinase Dendritic spine density
Acesso em linha:	http://link.springer.com/article/10.1186/s11689-017-9184-y
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