Sorafenib enforces HIV-1 latency by selectively inhibiting PKC-driven STAT1/3 serine 727 phosphorylation

ABSTRACT Eliminating the latent HIV-1 reservoir remains a major barrier to achieving a functional cure. The “block-and-lock” strategy aims to enforce durable transcriptional silencing of proviruses, thereby preventing viral rebound upon interruption of antiretroviral therapy. However, the molecular...

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Hlavní autoři:	Peipei Wang, Zhuoyue Meng, Jiasheng Zhou, Huixin Wu, Wei Wang, Zhiliang Gao, Ying Zhang, Jinfeng Cai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	ASM 2026-09-01
Edice:	Antimicrobial Agents and Chemotherapy
Témata:	HIV-1 sorafenib latency-promoting agent STAT1/3 Ser727
On-line přístup:	https://journals.asm.org/doi/10.1128/aac.00540-26
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