MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, but identifying genes robustly regulated by MeCP2 has been difficult. By integrating multiple transcriptomics d...

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Bibliografiske detaljer

Principais autores:	Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Y Zoghbi
Format:	Artigo
Sprog:	Inglês
Udgivet:	eLife Sciences Publications Ltd 2023-02-01
Serier:	eLife
Fag:	growth differentiation factor 11 Methyl CpG Binding Protein 2 MECP2 duplication syndrome GDF11 MeCP2
Online adgang:	https://elifesciences.org/articles/83806
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