Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas

The tuberous sclerosis complex (TSC) is a rare genetic syndrome and multisystem disease resulting in tumor formation in major organs. A molecular hallmark of TSC is a dysregulation of the mammalian target of rapamycin (mTOR) through loss-of-function mutations in either tumor suppressor TSC1 or TSC2....

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Autori principali:	Robert M. Vaughan, Jennifer J. Kordich, Chun-Yuan Chan, Nanda K. Sasi, Stephanie L. Celano, Kellie A. Sisson, Megan Van Baren, Matthew G. Kortus, Dean J. Aguiar, Katie R. Martin, Jeffrey P. MacKeigan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-03-01
Serie:	Frontiers in Oncology
Soggetti:	Chk1/2 CHEK1/2 TSC2 tuberous sclerosis complex mTOR checkpoint kinase inhibitors
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2022.852859/full
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