One-Step Suicide Substrate Inactivation Kinetics of a Ping-Pong Reaction with One Substrate Undergoing Disproportionation: A Theoretical Approach with Approximate Solutions

Understanding the kinetic mechanism of enzyme inactivation by suicide substrate is of relevance for the optimal design of new drugs with pharmacological and therapeutic applications. Suicide substrate inactivation usually occurs via a two-step mechanism, although there are enzymes such as peroxidase...

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Auteurs principaux:	Ismael Gutiérrez-Fernández, Ouardia Bendou, Nara Bueno-Ramos, Emilio L. Marcos-Barbero, Rosa Morcuende, Juan B. Arellano
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-11-01
Collection:	Mathematics
Sujets:	catalase enzymatic kinetics disproportionation reaction Michaelis–Menten model ping-pong reaction reactant stationary assumption
Accès en ligne:	https://www.mdpi.com/2227-7390/10/22/4240
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