Chronic kidney disease induces a distinct lipidomic signature and accelerates atherosclerosis progression in a novel minipig model

Abstract Background Chronic kidney disease (CKD) markedly accelerates atherosclerosis, driving the excess cardiovascular morbidity and mortality in these patients. While rodent models have been indispensable for mechanistic studies, their small vessel size limits the use of non-invasive vascular ima...

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Main Authors:	Marcelino Bermúdez-López, Paula Nogales, Manuel Martí-Antonio, Eva Castro-Boqué, Virtudes M. de Lamo, Laia Beà-Menchón, Sergio Luis-Lima, Esteban Porrini, Xavier Sanchez-Salguero, Mariona Jové, Elia Obis, Natàlia Mota-Martorell, Aurora Pérez-Gómez, Alicia Garcia-Carrasco, Milica Bozic, Jesús Guajardo, Carlos J. Pérez-Sánchez, Serafí Cambray, Núria Amigó, Reinald Pamplona, Jacob F. Bentzon, José M. Valdivielso
Format:	Artigo
Language:	Inglês
Published:	BMC 2026-04-01
Series:	Laboratory Animal Research
Subjects:	Atherosclerosis CKD Contrast-enhanced ultrasound Palmitic acid Pig Swine
Online Access:	https://doi.org/10.1186/s42826-026-00274-w
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