Código QR (código de barras bidimensional)

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

Approximately 70% of KRAS-positive colorectal cancers (CRCs) have a CpG island methylator phenotype (CIMP) characterized by aberrant DNA hypermethylation and transcriptional silencing of many genes. The factors involved in, and the mechanistic basis of, CIMP is not understood. Among the CIMP genes a...

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Principais autores: Ryan W Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, Michael R Green
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2014-03-01
coleção:eLife
Assuntos:
CpG island methylator phenotype
INK4-ARF
colorectal cancer
ZNF304
KRAS
DNMT1
Acesso em linha:https://elifesciences.org/articles/02313
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