CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs

IntroductionSecondary and tertiary lymphoid structures are a critical target of suppression in many autoimmune disorders, protein replacement therapies, and in transplantation. Although antigen-specific regulatory T cells (Tregs), such as chimeric antigen receptor (CAR) Tregs, generally persist long...

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Autores principales:	Matteo Doglio, Jyoti Rana, Adriana Stucchi, Maite-Muñoz Melero, Alessia Ugolini, Tatiana Jofra, Cristiano Toma, Clara Bercher-Brayer, Pierluigi Carulli, Sandeep Kumar, Paolo Monti, Elisa Martini, Senthilkumar Thirumurugan, Moanaro Biswas, Chiara Bonini, Georgia Fousteri
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-07-01
Colección:	Frontiers in Immunology
Materias:	regulatory T cells (Tregs) C-X-C chemokine receptor type 5 (CXCR5) type 1 diabetes (T1D) pancreatic islet transplantation hemophilia chimeric antigen receptor (CAR)
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513009/full
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