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Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder

Abstract Background Elevated plasma homocysteine levels, known as hyperhomocysteinemia, have been identified as an independent risk factor for atherosclerosis and related cardiovascular diseases. Macrophage pyroptosis-mediated inflammation is crucial in the development of atherosclerosis, but the un...

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Principais autores: Shan Zhang, Ying Lv, Xing Luo, Xiuzhu Weng, Jinyu Qi, Xiaoxuan Bai, Chen Zhao, Ming Zeng, Xiaoyi Bao, Xinyu Dai, Ying Zhang, Yuwu Chen, Minghao Liu, Sining Hu, Ji Li, Haibo Jia
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-06-01
Serier:Molecular Medicine
Fag:
Atherosclerosis
Calcium disorder
Homocysteine
Hyperhomocysteinemia
Inflammasome
Pyroptosis
Online adgang:https://doi.org/10.1186/s10020-023-00656-z
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