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NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury

Peripheral nerve lesions provoke apoptosis in the dorsal horn of the spinal cord. The cause of cell death, the involvement of neurons, and the relevance for the processing of somatosensory information are controversial. Here, we demonstrate in a mouse model of sciatic nerve injury that glutamate-ind...

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Principais autores: Perrine Inquimbert, Martin Moll, Alban Latremoliere, Chi-Kun Tong, John Whang, Gregory F. Sheehan, Brendan M. Smith, Erica Korb, Maria C.P. Athié, Olusegun Babaniyi, Nader Ghasemlou, Yuchio Yanagawa, C. David Allis, Patrick R. Hof, Joachim Scholz
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018-05-01
Series:Cell Reports
Assuntos:
NMDA receptor
excitotoxicity
disinhibition
dorsal horn
nerve injury
neuropathic pain
chronic pain
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124718307058
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