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ZPR1-Dependent Neurodegeneration Is Mediated by the JNK Signaling Pathway

The zinc finger protein ZPR1 deficiency causes neurodegeneration and results in a mild spinal muscular atrophy (SMA)-like disease in mice with reduced Zpr1 gene dosage. Mutation of the survival motor neuron 1 ( SMN1 ) gene causes SMA. Spinal muscular atrophy is characterized by the degeneration of t...

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Auteurs principaux: Xiaoting Jiang, Annapoorna Kannan, Laxman Gangwani
Format: Artigo
Langue:Inglês
Publié: SAGE Publishing 2019-08-01
Collection:Journal of Experimental Neuroscience
Accès en ligne:https://doi.org/10.1177/1179069519867915
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