Two-stage group-sequential designs with delayed responses – what is the point of applying corresponding methods?

Abstract Background In group-sequential designs, it is typically assumed that there is no time gap between patient enrollment and outcome measurement in clinical trials. However, in practice, there is usually a lag between the two time points. This can affect the statistical analysis of the data, es...

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Prif Awduron:	Stephen Schüürhuis, Gernot Wassmer, Meinhard Kieser, Friedrich Pahlke, Cornelia Ursula Kunz, Carolin Herrmann
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2024-10-01
Cyfres:	BMC Medical Research Methodology
Pynciau:	Group-sequential design Delayed response Pipeline data Performance evaluation Conditional performance score rpact
Mynediad Ar-lein:	https://doi.org/10.1186/s12874-024-02363-7
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