5‐ALA/SFC enhances HO‐1 expression through the MAPK/Nrf2 antioxidant pathway and attenuates murine tubular epithelial cell apoptosis

Cyclosporin A (CsA) is a common immunosuppressant, but its use is limited as it can cause chronic kidney injury. Oxidative stress and apoptosis play a key role in CsA‐induced nephrotoxicity. This study investigated the protective effect of 5‐aminolevulinic acid and iron (5‐ALA/SFC) on CsA‐induced in...

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Hauptverfasser:	Chi Liu, Masayuki Fujino, Shuoji Zhu, Yoshitaka Isaka, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Ping Zhu, Xiao‐Kang Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2019-11-01
Schriftenreihe:	FEBS Open Bio
Schlagworte:	5‐aminolevulinic acid apoptosis Cyclosporine A heme oxygenase‐1 oxidative stress
Online-Zugang:	https://doi.org/10.1002/2211-5463.12729
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