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Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome

Abstract Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target of rapamycin (InR/TOR) pathway. However, the biochemical context...

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Main Authors: Timo Glatter, Ralf B Schittenhelm, Oliver Rinner, Katarzyna Roguska, Alexander Wepf, Martin A Jünger, Katja Köhler, Irena Jevtov, Hyungwon Choi, Alexander Schmidt, Alexey I Nesvizhskii, Hugo Stocker, Ernst Hafen, Ruedi Aebersold, Matthias Gstaiger
Format: Artigo
Language:Inglês
Published: Springer Nature 2011-11-01
Series:Molecular Systems Biology
Subjects:
cell growth
InR/TOR pathway
interaction proteome
quantitative mass spectrometry
signaling
Online Access:https://doi.org/10.1038/msb.2011.79
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