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Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37

The deployment of the innate immune system in humans is essential to protect us from infection. Human cathelicidin LL-37 is a linear host defense peptide with both antimicrobial and immune modulatory properties. Despite years of studies of numerous peptides, SK-24, corresponding to the long hydropho...

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Autori principali: Yingxia Zhang, Jayaram Lakshmaiah Narayana, Qianhui Wu, Xiangli Dang, Guangshun Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-11-01
Serie:Pharmaceuticals
Soggetti:
antimicrobial peptides
biofilms
cathelicidin
LL-37 oligomerization
SK-24
structure-based design
Accesso online:https://www.mdpi.com/1424-8247/14/12/1245
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