Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Short QT syndrome (SQTS) is associated with tachyarrhythmias and sudden cardiac death. So far, only quinidine has been demonstrated to be effective in patients with SQTS type 1(SQTS1). The aim of this study was to investigate the mechanisms of disopyramide underlying its antiarrhythmic effects in SQ...

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Auteurs principaux:	Huan Lan, Qiang Xu, Ibrahim El-Battrawy, Rujia Zhong, Xin Li, Siegfried Lang, Lukas Cyganek, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2020-10-01
Collection:	Frontiers in Pharmacology
Sujets:	short QT syndrome arrhythmias antiarrhythmic drugs disopyramide human-induced pluripotent stem cell-derived cardiomyocytes
Accès en ligne:	https://www.frontiersin.org/article/10.3389/fphar.2020.554422/full
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