Quantitative Measurement of the Kinase Activity of Wildtype ALPK1 and Disease-Causing ALPK1 Mutants Using Cell-Free Radiometric Phosphorylation Assays
ALPK1 is an atypical protein kinase that is activated during bacterial infection by ADP-heptose and phosphorylates TIFA to activate a cell signaling pathway. In contrast, specific mutations in ALPK1 allow it to also be activated by endogenous human nucleotide sugars such as UDP-mannose, leading to t...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Bio-protocol LLC
2024-11-01
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| coleção: | Bio-Protocol |
| Acesso em linha: | https://bio-protocol.org/en/bpdetail?id=5124&type=0 |
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