Time-series analysis of rhenium(I) organometallic covalent binding to a model protein for drug development

Metal-based complexes with their unique chemical properties, including multiple oxidation states, radio-nuclear capabilities and various coordination geometries yield value as potential pharmaceuticals. Understanding the interactions between metals and biological systems will prove key for site-spec...

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Principais autores:	Francois J.F. Jacobs, John R. Helliwell, Alice Brink
Formato:	Artigo
Idioma:	Inglês
Publicado em:	International Union of Crystallography 2024-05-01
coleção:	IUCrJ
Assuntos:	fragment-based covalent drug design covalent drug discovery time series macromolecular crystallography anomalous difference density induced fit docking artificial metalloproteins infra-red spectroscopy
Acesso em linha:	http://scripts.iucr.org/cgi-bin/paper?S2052252524002598
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