IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene

IntroductionBrain metastasis (BM) is the most common and serious complication of breast cancer (BC). There is significant interest in investigating the crosstalk between BC cells and immune cells. β-elemene is the main pharmacodynamic component of Curcumae Rhizoma, a traditional Chinese medicine tha...

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Hlavní autoři:	Qian Feng, Cai-Zhi Li, Yi-Hua Zou, Xue-Yu Wang, Xia Yang, Rong Zhang, Zhong-Qiu Liu, Rong-Rong Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-05-01
Edice:	Frontiers in Pharmacology
Témata:	breast cancer brain metastasis M2 microglia IL6 and CCL2 cytokines IL6-STAT3 signaling pathway β-elemene
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1547333/full
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