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Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

Cdc10‐dependent transcript 1 (CDT1) is an essential protein for DNA replication licensing, which loads the mini‐chromosome maintenance (MCM) complex onto replication origins. We previously reported that excess CDT1 inhibits the elongation of nascent strands during DNA replication in Xenopus egg extr...

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Principais autores: Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-02-01
Serier:FEBS Open Bio
Fag:
CDT1
CMG helicase
DNA replication licensing
replication fork
replication stress
Online adgang:https://doi.org/10.1002/2211-5463.70127
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