Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study

Background: Previous studies have suggested that proton pump inhibitors could impair the antiplatelet effect of clopidogrel. It is uncertain whether ilaprazole affects the antiplatelet effect of clopidogrel. This study aimed to determine the drug-drug interaction between ilaprazole and clopidogrel.M...

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Principais autores:	Zekang Ye, Pengsheng Chen, Chuchu Tan, Xiaoxuan Gong, Ran Li, Zhou Dong, Inam Ullah, Chen Zhou, Sufeng Zhou, Lijun Xie, Xuemei Hou, Zhihui Han, Qian Gu, Jiazheng Ma, Jianzhen Teng, Yingdan Tang, Zhuanxia Zhang, Haitang Hu, Quankun Zhuang, Juan Chen, Bei Zhu, Feng Shao, Chunjian Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-09-01
coleção:	Frontiers in Pharmacology
Assuntos:	clopidogrel ilaprazole drug-drug interaction maximal platelet aggregation platelet reactivity index
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2022.952804/full
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