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Theoretical Prediction and Explanation of Reaction Site Selectivity in the Addition of a Phenoxy Group to Perfluoropyrimidine, Perfluoropyridazine, and Perfluoropyrazine

Perfluoroaromatics, such as perfluoropyridine and perfluorobenzene, are privileged synthetic scaffolds in organofluorine methodology, undergoing a series of regioselective substitution reactions with a variety of nucleophiles. This unique chemical behavior allows for the synthesis of many perfluoroa...

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Principais autores: Timothy J. Fuhrer, Matthew Houck, Rachel M. Chapman, Scott T. Iacono
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2021-12-01
Serija:Molecules
Teme:
Online dostop:https://www.mdpi.com/1420-3049/26/24/7637
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